March 17, 2025

College football odds, lines, schedule for Week 2: Ohio State opens as two-touchdown favorite vs. Oregon

Getty Images Lines for Week 2 of the college football season have been posted, and it’s never too early to get an idea of where you’ll want to put your money ahead of time. The second full week of the season doesn’t offer nearly as many high-profile matchups as Week 1 — top College Football Playoff contenders like Alabama, Oklahoma and Clemson all face FCS opponents — but there are some big-time matchups between Power Five teams. Perhaps none of those is more prominent than a showdown between two potential conference champions, as Oregon heads East to take on Ohio State in Columbus, Ohio. There’s also one of the most heated rivalries in all the country taking place on Saturday when Iowa make a short trip across the state to face Iowa State. Let’s look at the biggest games and their spreads and try to figure out what it all…

Continue Reading: College football odds, lines, schedule for Week 2: Ohio State opens as two-touchdown favorite vs. Oregon